Hydrochloric Acid → HCID 15099437、化合物

HRID 1706380ノート

反応式

HRID 1706380 の反応式
[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([OH:16])=[O:15])=[C:11]([Cl:17])[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH2:25](O)[CH3:26]>>[CH2:1]([N:8]1[C:12]([CH2:13][C:14]([O:16][CH2:25][CH3:26])=[O:15])=[C:11]([Cl:17])[N:10]=[C:9]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 1920381-Benzyl-4-chloro-2-phenylimidazole-5-acetic acid

生成物 1

HCID 15099437HCID 15099437、化合物

実験手順

In 100 ml of ethanol was dissolved 6.53 g of 1-benzyl-2-phenyl-4-chloroimidazole-5-acetic acid and under ice-cooling, hydrogen chloride was introduced until saturation. The solution was further stirred at room temperature overnight. The reaction mixture was concentrated to dryness under reduced pressure and the concentrate was run onto a column of 200 g silica gel, elution being carried out with benzene-chloroform (1:1). By the above procedure was obtained 2.28 g of 1-benzyl-2-phenyl-4-chloro-5-ethoxycarbonylmethylimidazole as crude crystals, which were then recrystallized from diethyl ether-hexane. Colorless needles, m.p. 72°-73° C.

後処理

  1. temperatureunder ice-cooling
  2. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  3. washthe concentrate was run onto a column of 200 g silica gel, elution

出典と根拠

ORDレコード
ord-a124f841e7b4426d9cd426dc67a49c77
出典データセット
uspto-grants-1980_06
特許番号
US04207324

反応ノート

読み込み中…