Benzyl Chloride → 1-Benzyl-2-phenyl-4-chloro-5-formylimidazole

反応式

[C:1]1([C:7]2[NH:8][C:9]([CH:13]=[O:14])=[C:10]([Cl:12])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:15](Cl)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:15]([N:8]1[C:9]([CH:13]=[O:14])=[C:10]([Cl:12])[N:11]=[C:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

実験手順

In 150 ml of dimethylformamide, there were stirred 206.5 g of 2-phenyl-4-chloro-5-formylimidazole, 133 g of benzyl chloride and 103.5 g of anhydrous potassium carbonate at 110°-120° C. for an hour. The reaction mixture was poured in ice-water and the resulting precipitate was recovered by filtration and recrystallized from acetonitrile twice. By the above procedure was obtained 143 g of 1-benzyl-2-phenyl-4-chloro-5-formylimidazole as colorless needles, m.p. 117°-118° C.