4-Aminobenzonitrile → 4-(1H-Pyrrol-1-yl)benzonitrile
反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.CO[CH:12]1[CH2:16][CH2:15][CH:14](OC)O1>C1(C)C=CC=CC=1>[N:1]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1参加物
4
実験手順
A mixture of 4-aminobenzonitrile (50 g., 0.42 mole), 2,5-dimethoxytetrahydrofuran (56 g., 0.42 mole) and 4A molecular sieves (184 g) in toluene (560 ml) was heated under reflux for 24 hrs. The residue from evaporation was washed with pet. ether and then recrystallized from diisopropyl ether to yield 42.5 g (60%) of 4-(1-pyrrolyl)benzonitrile, m.p. 104°-106° C.
後処理
- temperaturewas heated
- temperatureunder reflux for 24 hrs
- customThe residue from evaporation
- washwas washed with pet. ether
- customrecrystallized from diisopropyl ether
出典と根拠
- ORDレコード
- ord-fcc08d14595a44be8de04a162ee93a80
- 出典データセット
- uspto-grants-1980_06
- 特許番号
- US04207329
反応ノート
読み込み中…