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Dichloromethane → 5-Chloro-2-methoxybenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 5-Chloro-N-{2-[4-(2-hydroxyethyl)phenyl]ethyl}-2-methoxybenzamide | HCID 23453115 | — |
| 生成物 | 5-Chloro-2-methoxybenzoyl chloride | HCID 12384176 | — |
| 生成物 | 4-(2-Hydroxyethyl)-phenethylamine | HCID 21831841 | — |
反応手順
The 2-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-ethanol (oil) used as starting material is obtained by the acylation of 2-[4-(2-aminoethyl)-phenyl]-ethanol (oil) with 5-chloro-2-methoxybenzoyl chloride in anhydrous methylene chloride in the presence of triethylamine as acid acceptor.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04207341 |
| 出典データセット | uspto-grants-1980_06 |
| ORD ID | ord-59164c5477194e0b9420b1506022f10b |
| 出典メモ | uspto-grants-1980_06 |