Potassium Carbonate → HCID 13723675、化合物

HRID 1706691ノート

反応式

HRID 1706691 の反応式
Br[CH:2]([CH2:8]Br)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:10][C:11]1[CH:12]=[C:13]([OH:19])[C:14](=[CH:16][C:17]=1[CH3:18])[OH:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:10][C:11]1[C:17]([CH3:18])=[CH:16][C:14]2[O:15][CH:2]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:8][O:19][C:13]=2[CH:12]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 97945Ethyl 2,3-dibromopropionateHCID 127302874,5-Dimethylbenzene-1,2-diol

生成物 1

HCID 13723675HCID 13723675、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
30 °C

実験手順

86 g of ethyl 2,3-dibromopropionate was added, over a 15-minute period, to a stirred mixture of 41 g of 6A, 97 g of potassium carbonate and 300 ml of acetone. The temperature of the mixture rose to 60° C. The mixture was refluxed for 19 hours, cooled to 30° C. and filtered. The solvent was evaporated from the filtrate under reduced pressure. The residue was recrystallized from hexane to give 6, mp: 71°-72° C.

後処理

  1. customrose to 60° C
  2. temperatureThe mixture was refluxed for 19 hours
  3. filtrationfiltered
  4. customThe solvent was evaporated from the filtrate under reduced pressure
  5. customThe residue was recrystallized from hexane
  6. customto give 6, mp: 71°-72° C.

出典と根拠

ORDレコード
ord-e58108ecf2e148408ec945bc59295362
出典データセット
uspto-grants-1980_06
特許番号
US04208424

反応ノート

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