3,5-Dimethyl-1H-pyrazole-1-carboxamidine mononitrate → 58579-77-4
反応式
C(O[C:4](=[O:16])[CH2:5][NH:6][CH2:7][C:8]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:9]=1[NH2:15])C.[N+]([O-])(O)=O.C[C:22]1C=C(C)N(C(N)=N)[N:23]=1>C(O)C>[CH3:14][C:13]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:8]=1[CH2:7][N:6]1[CH2:5][C:4](=[O:16])[NH:23][C:22]1=[N:15]2参加物
4
実験手順
A mixture of N-(2-amino-6-methylbenzyl)glycine ethyl ester (1.097 g, 0.0049 mole) and 3,5-dimethylpyrazole-1-carboxamidine nitrate (0.993 g, 0.0049 mole) in absolute ethanol (15 ml) was heated at reflux for 64 hours. The mixture then was filtered and the product washed with hot ethanol to yield the title compound (0.610 g, 61%); identical (ir, nmr) with authentic material prepared according to the procedure of J. Med. Chem., 18, 224 (1975)).
後処理
- temperaturewas heated
- temperatureat reflux for 64 hours
- filtrationThe mixture then was filtered
- washthe product washed with hot ethanol
出典と根拠
- ORDレコード
- ord-010268cdc6104f87b6776ca4b1bce98c
- 出典データセット
- uspto-grants-1980_06
- 特許番号
- US04208521
反応ノート
読み込み中…