Epichlorohydrin → 2-{[(4-Chloronaphthalen-1-yl)oxy]methyl}oxirane

HRID 1706899ノート

反応式

HRID 1706899 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][CH:3]=1.Cl[CH2:14][CH:15]1[CH2:17][O:16]1.[OH-].[K+]>O>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([O:12][CH2:14][CH:15]2[CH2:17][O:16]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7835EpichlorohydrinHCID 117874-Chloro-1-naphtholHCID 14797Potassium Hydroxide

生成物 1

HCID 57435422-{[(4-Chloronaphthalen-1-yl)oxy]methyl}oxirane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred mixture of 44.5 parts of 4-chloro-1-naphthalenol and 115 parts of 2-(chloromethyl)oxirane are added portionwise 17.1 parts of potassium hydroxide (exothermic reaction). When the exothermic reaction is ceased, the whole is heated to reflux and stirred at reflux temperature for 2 hours. Water is added and the whole is extracted twice with trichloromethane. The combined extracts are washed three times with water, dried and evaporated. The residue is distilled, yielding 45.3 parts of 2-[(4-chloro-1-naphthalenyloxy)methyl]oxirane; bp. 150°-151° C. at 0.2 mm. pressure.

後処理

  1. customWhen the exothermic reaction
  2. temperaturethe whole is heated
  3. temperatureto reflux
  4. temperatureat reflux temperature for 2 hours
  5. extractionthe whole is extracted twice with trichloromethane
  6. washThe combined extracts are washed three times with water
  7. customdried
  8. customevaporated
  9. distillationThe residue is distilled

出典と根拠

ORDレコード
ord-dec601b24d424f9a8e83dc54fdca4846
出典データセット
uspto-grants-1980_06
特許番号
US04209447

反応ノート

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