Acetic Acid → 2-Hydroxy-5-(3-trifluoromethylphenyl)nicotinic acid

HRID 1707086ノート

反応式

HRID 1707086 の反応式
[O:1]=[C:2]1C(C#N)=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[CH:4][NH:3]1.Cl.[C:21]([OH:24])(=[O:23])[CH3:22]>>[O:1]=[C:2]1[C:22]([C:21]([OH:24])=[O:23])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:17])([F:18])[F:19])[CH:11]=2)=[CH:4][NH:3]1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 27759136J-508S

生成物 1

HCID 100623412-Hydroxy-5-(3-trifluoromethylphenyl)nicotinic acid

実験手順

A mixture of 1.32 g. of 1,2-dihydro-2-oxo-5-[3-(trifluoromethyl)phenyl]-3-pyridinecarbonitrile and 140 ml. of 1:1 concentrated hydrochloric acid and glacial acetic acid is heated at reflux temperature for 16 hours. A white solid is separated which is collected by filtration and is washed with water and ethanol to give 1.05 g. of the product of the Example m.p. 295°-298° C. dec.

後処理

  1. additionA mixture of 1.32 g
  2. temperatureat reflux temperature for 16 hours
  3. customA white solid is separated which
  4. filtrationis collected by filtration
  5. washis washed with water and ethanol
  6. customto give 1.05 g

出典と根拠

ORDレコード
ord-d7af70aefe0e4e17b118973496cb1058
出典データセット
uspto-grants-1980_06
特許番号
US04209626

反応ノート

読み込み中…