化工社化工社 化学情報印刷レポート · 研究参考用
5-Fluorouracil → Tegafur
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Fluorouracil | HCID 3385 | — |
| 反応物 | Hexamethyldisilazane | HCID 13838 | — |
| 反応物 | Tin tetrachloride | HCID 24287 | — |
| 反応物 | Tetrahydro-2-methoxyfuran | HCID 47519 | — |
| 反応物 | Tetrahydro-2-furyl acetate | HCID 102657 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Tegafur | HCID 5386 | 87% |
反応手順
0.65 g. (5 mmol) of 5-fluorouracil was agitated in 50 ml. of absolute ethylene chloride for one hour with 0.65 g. (4 mmol) of HMDS, 0.43 g. (4 mmol) of TCS, and 1.56 g. (6 mmol) of SnCl4 ; then 0.65 g. (5 mmol) of 2-acetoxytetrahydrofuran or 0.51 g. (5 mmol) of 2-methoxytetrahydrofuran was added to the mixture, and the latter was agitated for 2 hours and 4 hours, respectively, at 24° C. The mixture was worked up as described in Example 1, giving in an 87% yield N1 -(2-tetrahydrofuryl)-5-fluorouracil, m.p. 165°-167° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04209613 |
| 出典データセット | uspto-grants-1980_06 |
| ORD ID | ord-9070a9e3beac4190a465513a1d707e4b |
| 出典メモ | uspto-grants-1980_06 |