Methanol → 5-(3,4-Dihydroxyphenyl)-5-oxo-pentanoic acid methyl ester
反応式
[OH:1][C:2]1[CH:3]=[C:4]([C:9](=[O:16])[CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[CH:6][C:7]=1[OH:8].[CH3:17]O>>[CH3:17][O:14][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([OH:1])[CH:3]=1)=[O:16]参加物
3
実験手順
A solution of 5.6g of 5-(3,4-dihydroxyphenyl)-5-oxopentanoic acid in 300 ml of methanol is stirred together with 15g of Amberlyst 15 for 16 hours at room temperature. The reaction mixture is filtered on diatomaceous earth, concentrated by evaporation and the residue is chromatographed on silica gel with hexane/ethyl acetate (20-60%). 3.7 g of 5-(3,4-dihydroxyphenyl)-5-oxo-pentanoic acid methyl ester of melting point 104°-106° C. is obtained.
後処理
- filtrationThe reaction mixture is filtered on diatomaceous earth
- concentrationconcentrated by evaporation
- customthe residue is chromatographed on silica gel with hexane/ethyl acetate (20-60%)
出典と根拠
- ORDレコード
- ord-f08fef406bd947cbb6dd38c2b071d960
- 出典データセット
- uspto-grants-1994_10
- 特許番号
- US05352701
反応ノート
読み込み中…