Hydrochloric Acid → Piperazin-1-yl-pyridin-4-yl-methanone

HRID 1707631ノート

反応式

HRID 1707631 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1.Cl.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 15289251HCID 15289251、化合物

生成物 1

HCID 876553Piperazin-1-yl-pyridin-4-yl-methanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title material was synthesized from the title product of Example 26 (1.3 g, 4.46 mmol) by the method described in Example 25, except that the title free base was generated by treatment of its HCl salt with 0.5N K2CO3 in CH2Cl2. The CH2Cl2 solution was dried over Na2SO4 and all solvent removed under reduced pressure to provide 333 mg of the title free base. This material was used without further purification.

後処理

  1. dry with materialThe CH2Cl2 solution was dried over Na2SO4
  2. customall solvent removed under reduced pressure
  3. customto provide 333 mg of the title free base
  4. customThis material was used without further purification

出典と根拠

ORDレコード
ord-8f1c74933a8048a0a466d1baba5ba83c
出典データセット
uspto-grants-1994_10
特許番号
US05354747

反応ノート

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