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1-[2-(4-Pyridinyl)ethyl]piperazine → 8-Chloro-10,11-dihydro-10-[[4-[2-(4-pyridinyl)ethyl]-1-piperazinyl]carbonyl]dibenz[b,f][1,4]oxazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[2-(4-Pyridinyl)ethyl]piperazine | HCID 558685 | — |
| 反応物 | 8-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride | HCID 14975983 | — |
| 生成物 | 8-Chloro-10,11-dihydro-10-[[4-[2-(4-pyridinyl)ethyl]-1-piperazinyl]carbonyl]dibenz[b,f][1,4]oxazepine | HCID 15224926 | 291.3% |
反応手順
The title compound of Example 2 (0.38 g, 1.3 mmol) was combined with the product of Example 88 (0.25 g, 1.3 mmol) and the reaction was carried out by the method of Example 4. Following chromatographic separation, 1.7 g of the white solid title product was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05354747 |
| 出典データセット | uspto-grants-1994_10 |
| ORD ID | ord-525a2e45e5144ec48c3316b67909b848 |
| 出典メモ | uspto-grants-1994_10 |