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Trifluoroacetic acid → 4,6-Bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4,6-Bis(1,1-dimethylethyl)-5-[(2-methoxyethoxy)-methoxy]-2-pyrimidinecarbonitrile | HCID 19922986 | — |
| 生成物 | 4,6-Bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile | HCID 15294897 | 68.2% |
反応手順
According to the procedure of Example 18, 4,6-bis (1,1-dimethylethyl)-5-[(2-methoxyethoxy)-methoxy]-2-pyrimidine carbonitrile (9.1 g, 28.3 mmol) is treated with trifluoroacetic acid to give 4,6-bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile (4.5 g, 68%); mp 203°-205° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05356898 |
| 出典データセット | uspto-grants-1994_10 |
| ORD ID | ord-436bc5199a544bd2a820128beee35ebb |
| 出典メモ | uspto-grants-1994_10 |