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Sodium Hydroxide → 2-(4-Toluyl)terephthalic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | [1,1'-Biphenyl]-2,5-dicarboxylic acid, 4'-methyl-, 2,5-dimethyl ester | HCID 105655 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(4-Toluyl)terephthalic acid | HCID 15661445 | 66.2% |
反応手順
Dimethyl2-(4-tolyl)terephthalate (11.88 g) was suspended in methanol (99 ml). 5M NaOH (50 ml) was added. The reaction mixture was heated at reflux for 1.5 hours. The methanol was removed under reduced pressure. The residue was treated with ethyl acetate and water and the layers separated. The aqueous layer was washed once with ethyl acetate. The aqueous layer was then acidified with 2N HCl and extracted three times with ethyl acetate. These combined organic extracts were then dried over MgSO4, filtered and evaporated under reduced pressure which gave the product (7.09 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05356889 |
| 出典データセット | uspto-grants-1994_10 |
| ORD ID | ord-7bdac893758244e2ba0ab1b3eb9eee4c |
| 出典メモ | uspto-grants-1994_10 |