関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfur | HCID 5362487 | — |
| 反応物 | 3-(1-Acetyl-l,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine | HCID 19957261 | — |
| 溶媒 | Decalin | HCID 7044 | — |
| 生成物 | 2-(4-Fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine | HCID 19957277 | 49.1% |
反応手順
A mixture of 3-(1-acetyl-1,2-dihydro-2-methylpyridin-4-yl)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidine (315 mg) and sulfur (146 mg) in decaline (3 ml) was stirred at 190° C. for 2 hours. The reaction mixture was cooled and purified by column chromatography on silica gel to give 2-(4-fluorophenyl)-3-(2-methylpyridin-4-yl)pyrazolo[1,5-a]pyrimidine (135 mg) as crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05356897 |
|---|
| 出典データセット | uspto-grants-1994_10 |
|---|
| ORD ID | ord-e456eb84833d49f0858b35c8c7319e96 |
|---|
| 出典メモ | uspto-grants-1994_10 |
|---|
