2-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride → 2-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride

HRID 1708027ノート

反応式

HRID 1708027 の反応式
[ClH:1].Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:13]3[NH:14][CH2:15][CH2:16][CH2:17][N:12]3[N:11]=2)=[CH:6][CH:5]=1>C(O)(C)C>[ClH:1].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:13]3[NH:14][CH2:15][CH2:16][CH2:17][N:12]3[N:11]=2)=[CH:6][CH:5]=1

参加物

3

反応物 1

HCID 1363784152-(4-Fluorophenyl)-3-(pyridin-4-yl)4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride

生成物 1

HCID 1363784182-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride収率 49.7%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

2-(4-Fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine dihydrochloride (183 mg) was dissolved in hot aqueous isopropyl alcohol solution (5.5 ml). The solution was cooled and the separated solid was collected, washed with isopropyl alcohol and dried to give 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine hydrochloride (82 mg).

後処理

  1. temperatureThe solution was cooled
  2. customthe separated solid was collected
  3. washwashed with isopropyl alcohol
  4. customdried

出典と根拠

ORDレコード
ord-27b4b01e83ae409198a05e10d2595612
出典データセット
uspto-grants-1994_10
特許番号
US05356897

反応ノート

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