Ammonia → 6-Butyl-4-carbamoyl-2-oxo-1,2-dihydropyridine

HRID 1708146ノート

反応式

HRID 1708146 の反応式
[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12]([O:14]C)=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[NH3:16]>C(O)C>[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12](=[O:14])[NH2:16])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 222Ammonia2 回HCID 152251016-Butyl-4-methoxycarbonyl-2-oxo-1,2-dihydropyridine

生成物 1

HCID 189608186-Butyl-4-carbamoyl-2-oxo-1,2-dihydropyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3 g (14.3mmol) of the compound from Example 1 are heated for a few minutes in 10 ml of ethanol and 20 ml of conc. ammonia. A further 5 ml of conc. ammonia are then added three times each and the mixture is again briefly heated to boiling. After cooling, the precipitate is filtered off with suction and dried over P2O5 in vacuo.

後処理

  1. temperatureis again briefly heated to boiling
  2. temperatureAfter cooling
  3. filtrationthe precipitate is filtered off with suction
  4. dry with materialdried over P2O5 in vacuo

出典と根拠

ORDレコード
ord-62b55189dfa94ea3981f2520f962ecf7
出典データセット
uspto-grants-1994_10
特許番号
US05356911

反応ノート

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