P-Cresol → HCID 18961263、化合物
反応式
[CH:1]1[C:6](O)=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[C:9]([CH2:12][O:13][C:14]1[CH:24]=[CH:23][C:17]([CH:18](O)[C:19]([OH:21])=[O:20])=[CH:16][CH:15]=1)([OH:11])=[O:10]>O>[C:9]([CH2:12][O:13][C:14]1[CH:24]=[CH:23][C:17]([CH:18]2[C:1]3[CH:2]=[C:3]([CH3:8])[CH:4]=[CH:5][C:6]=3[O:21][C:19]2=[O:20])=[CH:16][CH:15]=1)([OH:11])=[O:10]参加物
4
実験手順
A mixture of 41.6 g (0.39 mol) of p-cresol and 29.0 g (0.13 mol) of 4-carboxymethoxymandelic acid is maintained at 185° C. under a nitrogen atmosphere for 90 minutes, during which the water formed is distilled off. Excess p-cresol is then distilled off under reduced pressure. Crystallisation of the residue from 75 ml of xylene gives 31.4 g (81%) of 3-(4-carboxymethoxyphenyl)-5-methylbenzofuran-2-one, melting point 198°-203° C. (compound (101), Table 1).