Dimethylamine → N,N-dimethyl-{7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonamide

HRID 1708406

反応式

HRID 1708406 の反応式
[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[N:11]=[C:12]([S:14](Cl)(=[O:16])=[O:15])[N:13]=[C:6]2[C:5]=1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]#[N:32])=[CH:21][CH:20]=1)[CH2:2][CH3:3].[CH3:33][NH:34][CH3:35]>>[CH3:33][N:34]([CH3:35])[S:14]([C:12]1[N:13]=[C:6]2[N:7]([C:8]([CH3:10])=[N:9][C:4]([CH2:1][CH2:2][CH3:3])=[C:5]2[CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]#[N:32])=[CH:23][CH:24]=2)[N:11]=1)(=[O:15])=[O:16]

参加物

3

反応物 2

HCID 674DimethylamineHCID 18958826{7-n-Propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonyl chloride

生成物 1

HCID 10344843N,N-dimethyl-{7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonamide

実験手順

Formula (XII): R1 =n-propyl, R2 =methyl, X=N, Y=C--SO2N(CH3)2X Y=double bond, ##STR122## 8 g of {7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonyl chloride, prepared in Example 45, are stirred with 40 ml of a 40% aqueous solution of dimethylamine for one hour at 50° C. The mixture is then extracted with chloroform, and the organic phase is dried over magnesium sulphate and then concentrated under vacuum to give 5.5 g of N,N-dimethyl-{7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonamide in the form of crystals of melting point 158° C. The following examples were prepared according to the same procedure:

後処理

  1. extractionThe mixture is then extracted with chloroform
  2. dry with materialthe organic phase is dried over magnesium sulphate
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-9ef445e626d345819fda915a223522db
出典データセット
uspto-grants-1994_10
特許番号
US05358950

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