21,21-Dimethoxy-20-methylpregna-5,7-diene-1alpha,3betadiol → 1alpha,3beta-Dihydroxypregna-5,7-diene-20-carbaldehyde
反応式
C[O:2][CH:3](OC)[CH:4]([CH3:26])[C@@H:5]1[C@:22]2([CH3:23])[C@H:8]([C:9]3[C@H:19]([CH2:20][CH2:21]2)[C@:17]2([CH3:18])[C:12]([CH2:13][C@@H:14]([OH:25])[CH2:15][C@@H:16]2[OH:24])=[CH:11][CH:10]=3)[CH2:7][CH2:6]1.CC1(C)COC(C([C@@H]2[C@]3(C)[C@H](C4[C@H](CC3)[C@]3(C)C(C[C@@H](O)C[C@@H]3O)=CC=4)CC2)C)OC1>>[OH:24][C@@H:16]1[C@@:17]2([CH3:18])[C:12](=[CH:11][CH:10]=[C:9]3[C@@H:19]2[CH2:20][CH2:21][C@@:22]2([CH3:23])[C@H:8]3[CH2:7][CH2:6][C@@H:5]2[CH:4]([CH:3]=[O:2])[CH3:26])[CH2:13][C@@H:14]([OH:25])[CH2:15]1参加物
3
実験手順
The procedure of Example 25 was repeated except that 2.6 mg (0.00667 mmole) of 21,21-dimethoxy-20-methylpregna-5,7-diene-1α,3β-diol was used in lieu of 4.3 mg of 20-(5,5-dimethyl-1,3-dioxan-2-yl)pregna-5,7-diene-1α,3β-diol to give 1.8 mg of 1α,3β-dihydroxypregna-5,7-diene-20-carbaldehyde (yield: 78%).
出典と根拠
- ORDレコード