Beta-Alanine → 3-[(2-Nitrophenyl)amino]propanoic acid
反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15].C(N(CC)CC)C.O>CN(C)C=O>[C:14]([CH2:13][CH2:12][NH:11][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9])([OH:16])=[O:15]参加物
6
反応条件
- 温度
- 80 °C
実験手順
A mixture of 5.0 g (36 mmol) 2-fluoronitrobenzen, 6.3 g (71 mmol) β-alanin, 20 ml triethylamine, 50 ml water and 100 ml dimethylformamide was stirred at 80° C. for 10 h. After cooling to 25° C. the reaction mixture was evaporated in vacuo. The residue was stirred with IN hydrochloric acid, and the precipitate was filtered off and washed with water to give 3.6 g (48%) N- carboxyethyl-2-nitroaniline. M.p. 145° C., 1H-NMR (DMSO-d6): 8.2-6.2 (5H, m), 3.4 (2H, q), 2.5 (2H, t).
後処理
- temperatureAfter cooling to 25° C. the reaction mixture
- customwas evaporated in vacuo
- stirringThe residue was stirred with IN hydrochloric acid
- filtrationthe precipitate was filtered off
- washwashed with water
出典と根拠
- ORDレコード
- ord-147e6b1023dd4679ba3504529a8aac60
- 出典データセット
- uspto-grants-1990_08
- 特許番号
- US04948794
反応ノート
読み込み中…