1-Bromo-3-chloropropane → N-[3-(3-Chloropropoxy)phenyl]urea

関与物質

反応手順

A mixture of 45.6 g (0.3 mole of 1-(3-hydroxyphenyl)urea, 94.5 g (0.6 mole) of 1-bromo-3-chloropropane, 124.4 g (0.9 mole) of anhydrous potassium carbonate and 1 liter of acetone was heated at reflux with mechanical stirring for 20 hr. The mixture was concentrated and the residue was slurried with 1.5 liters of water. The mixture was filtered and the filter cake was recrystallized from 2-propanol to yield 57.0 g (83%) of off-white solid, m.p. 141°-143° C.

情報源と証拠