化工社化工社 化学情報印刷レポート · 研究参考用
Benzalkonium Chloride → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzalkonium Chloride | HCID 3014024 | — |
| 反応物 | Timolol Maleate | HCID 5281056 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | Betaxolol Hydrochloride | HCID 107952 | — |
反応手順
Timolol maleate powder was from Merck, Sharp and Dohme (West Point, Pa.) and was dissolved in 0.5% polysorbate 80 in normal saline with 0.01% benzalkonium chloride (40 mg/ml, and 20 mg/ml, respectively). Betaxolol hydrochloride (Betoptic; Alcon, Fort Worth, Tex.) at a concentration of 0.5% (5 mg/ml) and levobunalol hydrochloride (Betagan; Allergan, Irvine, Calif.) at a concentration of 0.5% (5 mg/ml), were obtained from the pharmacy.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04952581 |
| 出典データセット | uspto-grants-1990_08 |
| ORD ID | ord-7c2c3d85450b4229ba69dc8ec5a40455 |
| 出典メモ | uspto-grants-1990_08 |