Water → 4,5,5-Trifluoro-4-penten-1-ol

HRID 1710014ノート

反応式

HRID 1710014 の反応式
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8](=[C:14]([F:16])[F:15])[CH2:9][CH2:10][C:11](O)=[O:12].O>C(OCC)C>[F:7][C:8](=[C:14]([F:16])[F:15])[CH2:9][CH2:10][CH2:11][OH:12]

参加物

5

反応物 3

HCID 962WaterHCID 27824474,5,5-trifluoropent-4-enoic AcidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 27779334,5,5-Trifluoro-4-penten-1-ol収率 57.1%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a stirred suspension of 0.4 gram (0.01 mole) of lithium aluminum hydride in 20 ml of diethyl ether was added dropwise a solution of 1.5 grams (0.01 mole) of 4,5,5-trifluoro-4-pentenoic acid in 30 ml of diethyl ether. Upon completion of addition the reaction mixture was stirred at ambient temperature for one hour, then 20 ml of water was added carefully. The mixture was filtered and the filtrate concentrated under reduced pressure to give 0.8 gram of 4,5,5-trifluoro-4-penten-1-ol as an oil. The nmr and the ir spectra were consistent with the proposed structure.

後処理

  1. additionUpon completion of addition the reaction mixture
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-55f5c6633b8841daaa2ef5f0a3761a9c
出典データセット
uspto-grants-1990_08
特許番号
US04952580

反応ノート

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