2-[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl]-2-oxoacetic acid methyl ester → (3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidine
反応式
COC(=O)C([N:6]1[C@H:9]([S:10][C:11](=[O:13])[CH3:12])[C@@H:8]([O:14][CH3:15])[C:7]1=[O:16])=O>CO.C(Cl)Cl>[C:11]([S:10][C@H:9]1[NH:6][C:7](=[O:16])[C@@H:8]1[O:14][CH3:15])(=[O:13])[CH3:12]参加物
4
実験手順
A solution of 71.20 mg of 2[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl-2-oxoacetic acid methyl ester (crude product) in 10 ml of 1% aqueous methanol is stirred overnight at room temperature. The reaction mixture is diluted with methylene chloride, washed with water, dried over sodium sulphate and concentrated by evaporation in vacuo. The residue is chromatographed over silica gel with toluene/ethyl acetate (9:1) and yields the title compound.
後処理
- washwashed with water
- dry with materialdried over sodium sulphate
- concentrationconcentrated by evaporation in vacuo
- customThe residue is chromatographed over silica gel with toluene/ethyl acetate (9:1)
出典と根拠
- ORDレコード
- ord-0a48b089b0b9408e8e2ec64daeab463c
- 出典データセット
- uspto-grants-1990_08
- 特許番号
- US04952690
反応ノート
読み込み中…