2-[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl]-2-oxoacetic acid 2,2,2-trichloroethyl ester → (3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidine
反応式
ClC(Cl)(Cl)COC(=O)C([N:8]1[C@H:11]([S:12][C:13](=[O:15])[CH3:14])[C@@H:10]([O:16][CH3:17])[C:9]1=[O:18])=O>CO.C(OC)(=O)C.O>[C:13]([S:12][C@H:11]1[NH:8][C:9](=[O:18])[C@@H:10]1[O:16][CH3:17])(=[O:15])[CH3:14]参加物
5
実験手順
A solution of 1.52 g of 2-[(3S,4R)-4-acetylthio-3-methoxy-2-oxoazetidin-1-yl]-2-oxoacetic acid 2,2,2-trichloroethyl ester (crude product) in 290 ml of methanol, 40 ml of methyl acetate and 5.9 ml of water is refluxed for 20 minutes under nitrogen. The solvent is evaporated off in vacuo. After chromatography over silica gel with toluene/ethyl acetate (3:1) the residue yields the title compound.
後処理
- customThe solvent is evaporated off in vacuo
出典と根拠
- ORDレコード
- ord-9efb43ac130a4fb7a800ec706c2cd1ce
- 出典データセット
- uspto-grants-1990_08
- 特許番号
- US04952690
反応ノート
読み込み中…