4-Methyl-2-(2-Pyrazinyl)-1,3-Thiazole-5-Carbonyl Chloride → HCID 10365797、化合物

反応式

[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH2:17][CH2:16][CH2:15][NH:14][N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2].[CH3:18][C:19]1[N:20]=[C:21]([C:27]2[CH:32]=[N:31][CH:30]=[CH:29][N:28]=2)[S:22][C:23]=1[C:24](Cl)=[O:25]>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH2:17][CH2:16][CH2:15][N:14]([C:24]([C:23]3[S:22][C:21]([C:27]4[CH:32]=[N:31][CH:30]=[CH:29][N:28]=4)=[N:20][C:19]=3[CH3:18])=[O:25])[N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

参加物

反応物 2

HCID 27765064-Methyl-2-(2-Pyrazinyl)-1,3-Thiazole-5-Carbonyl Chloride

HCID 115938543-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazine

生成物 1

HCID 10365797HCID 10365797、化合物収率 86.4%

実験手順

Analogously to Example 2, reaction of 300 mg of 3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazine with 307 mg of 4-methyl-2-pyrazin-2-yl-thiazole-5-carbonyl chloride (“BC”) gives the compound 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyrazin-2-yl-thiazol-5-yl)methanone (484 mg, HPLC-MS m/e 438).

出典と根拠

ORDレコード: ord-fe4e1cfeb79b4b258d567e6be083a9ee
出典データセット: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07790723B2

反応ノート

読み込み中…