Tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate → 3-Difluoromethoxy-4-methoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-benzenesulfonamide Hydrochloride

HRID 1710614ノート

反応式

HRID 1710614 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:15]=2[O:21][CH3:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:23][CH:24]([F:38])[O:25][C:26]1[CH:27]=[C:28]([S:34]([Cl:37])(=[O:36])=[O:35])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33]>>[ClH:37].[F:38][CH:24]([F:23])[O:25][C:26]1[CH:27]=[C:28]([S:34]([NH:20][C:18]2[CH:17]=[CH:16][C:15]([O:21][CH3:22])=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=2)(=[O:36])=[O:35])[CH:29]=[CH:30][C:31]=1[O:32][CH3:33]

参加物

3

反応物 2

HCID 10686178Tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylateHCID 451330813-(Difluoromethoxy)-4-methoxybenzenesulfonyl chloride

生成物 1

HCID 670946163-Difluoromethoxy-4-methoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-benzenesulfonamide Hydrochloride

実験手順

The compound was prepared as described for Example 1 by reaction of 4-(5-amino-2-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and commercially available 3-difluoromethoxy-4-methoxy benzene sulfonylchloride, followed by deprotection under acidic conditions.

後処理

  1. customThe compound was prepared

出典と根拠

ORDレコード
ord-d78e1f5ae63449148a4ccdfb71b40d15
出典データセット
uspto-grants-2010_09
特許番号
US07790727B2

反応ノート

読み込み中…