Hydrochloric Acid → Hydrochloric Acid

HRID 1710666ノート

反応式

HRID 1710666 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([O:22][CH3:23])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.CCOCC>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:11]2([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[CH:16][C:17]=1[O:22][CH3:23].[ClH:24]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 68503586HCID 68503586、化合物

生成物 2

HCID 313Hydrochloric AcidHCID 578055554-(4-Chloro-3-methoxyphenyl)-4-piperidinol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
0 °C

実験手順

To a solution of 4-(4-Chloro-3-methoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (502 mg) in MeOH (5 mL) was added a solution of HCl in ether (2 M, 9.5 mL). The resultant mixture was stirred at room temperature for 1 h followed by the addition of ether (50 mL). The reaction mixture was stirred at 0° C. for an additional 30 min, then filtered and concentrated to provide 4-(4-Chloro-3-methoxy-phenyl)-piperidin-4-ol (69) in the form of HCl salt as a white solid.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-6aec36300d7b4412a37972bd09961c23
出典データセット
uspto-grants-2010_09
特許番号
US07790726B2

反応ノート

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