Acetic Acid → 3-(3-Chloro-2-methyl-phenyl)-imidazolidin-4-one
反応式
[NH2:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[C:7]=1[CH3:13])=[O:4].[C:14](O)(=O)C>>[Cl:12][C:8]1[C:7]([CH3:13])=[C:6]([N:5]2[C:3](=[O:4])[CH2:2][NH:1][CH2:14]2)[CH:11]=[CH:10][CH:9]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
A mixture of 2-amino-N-(3-chloro-2-methyl-phenyl)-acetamide (74) (1.18 g, 1 equiv), paraformaldehyde (HCHO)n (0.77 g, 1.5 equiv) and 3 mL of acetic acid was heated at 90° C. for 3 h and evaporated to dryness to afford 3-(3-chloro-2-methyl-phenyl)-imidazolidin-4-one (75) as acetic acid salt.
後処理
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-cbd1f025f45747c5a5357cd360964bc1
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07790726B2
反応ノート
読み込み中…