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N-bromobutanimide → 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 4-Amino-N-(1,1-dimethylethyl)benzenesulfonamide | HCID 832627 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide | HCID 54850284 | 53.1% |
反応手順
To a solution of 4-amino-N-tert-butyl-benzenesulfonamide (J. Med. Chem. (2003), 46(16), 3463-3475, 228 mg, 1.00 mmol) in DCM (10 mL), NBS (178 mg, 1.00 mmol) was added. The resulting mixture was stirred at RT for 30 min and washed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL). The organic layer was separated, dried and concentrated to obtain 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide (163 mg, 53%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07790724B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-82168f1fbbe246799a59bd1f0f3f1298 |
| 出典メモ | uspto-grants-2010_09 |