化工社化工社 化学情報印刷レポート · 研究参考用
Water → 7-Iodo-3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | N-Iodosuccinimide | HCID 120273 | — |
| 反応物 | 3-(4-Phenoxyphenyl)thieno[3,2-c]pyridin-4-amine | HCID 18450763 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-Iodo-3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine | HCID 18450878 | 70% |
反応手順
A solution of Example 10A (1.69 g, 5.3 mmol) in DMF (20 mL) was treated with NIS (1.26 g, 5.6 mmol), stirred at room temperature for 3 hours, poured into water, and filtered. The filter cake was purified by flash column chromatography on silica gel with 15% ethyl acetate/hexanes to provide 1.64 g (70% yield) of the desired product. MS (ESI(+)) m/e 444.8 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737160B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-4913f3f3dcaf4671a8270d6e845f5975 |
| 出典メモ | uspto-grants-2010_06 |