1,2,4,5-Tetrafluorobenzene → (2,3,5,6-Tetrafluorophenyl)methanamine

HRID 1712215

反応式

HRID 1712215 の反応式
FC1C(F)=CC(F)=C(F)C=1.[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:13]=1[C:14]#[N:15].C(C1(C(F)=C(F)C=C(F)C1F)C=O)#N>>[F:11][C:12]1[C:19]([F:20])=[CH:18][C:17]([F:21])=[C:16]([F:22])[C:13]=1[CH2:14][NH2:15]

参加物

4

反応物 3

HCID 94741,2,4,5-TetrafluorobenzeneHCID 2975462,3,5,6-TetrafluorobenzonitrileHCID 866412531-Cyano-2,3,5,6-tetrafluorobenzaldehyde

生成物 1

HCID 53849533(2,3,5,6-Tetrafluorophenyl)methanamine

実験手順

From the toluene extract, a small amount of a sample was withdrawn, and it was subjected to GC analysis. As a result of the analysis, a peak of the tetrafluoroterephthalonitrile as a raw material was below the detection limit, and tetrafluoroterephthalaldehyde was obtained in an amount of only 14.5 mol %. The amount of 2,3,5,6-tetrafluorobenzene was 0.81 mol %, the amount of 2,3,5,6-tetrafluorobenzonitrile was 0.67 mol %, and 1-cyano-2,3,5,6-tetrafluorobenzaldehyde wherein a nitrile group on only one side had reacted was obtained in an amount of 54.0 mol %. On the other hand, the aqueous phase was neutralized and then subjected to GC analysis. As a result of the analysis, presence of 0.04 mol % of 2,3,5,6-tetrafluorobenzylamine was confirmed. The results are set forth in Table 2.

後処理

  1. customhad reacted
  2. customwas obtained in an amount of 54.0 mol %

出典と根拠

ORDレコード
ord-0aab16f5e7a8480392751af636b04e3c
出典データセット
uspto-grants-2010_09
特許番号
US07790931B2

関連ノート

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