化工社化工社 化学情報印刷レポート · 研究参考用
Benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate → Benzyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[4-methyl-3-(2-triisopropylsilanyloxyethoxy)benzyloxy]piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate | HCID 68499596 | — |
| 反応物 | [2-(5-Chloromethyl-2-methylphenoxy)ethoxy]triisopropylsilane | HCID 68504955 | — |
| 生成物 | Benzyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-[4-methyl-3-(2-triisopropylsilanyloxyethoxy)benzyloxy]piperidine-1-carboxylate | HCID 68503397 | — |
反応手順
Analogously to Method D, 0.700 g of benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)-propoxy]phenyl}piperidine-1-carboxylate (Example 10f) and [2-(5-chloromethyl-2-methyl-phenoxy)ethoxy]triisopropylsilane are reacted. The title compound is obtained as a colourless oil. Rf=0.41 (1:2 EtOAc-heptane); Rt=7.94.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07790715B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-2cfbac5f8f1e4cc0aa85c2c323a76562 |
| 出典メモ | uspto-grants-2010_09 |