Methylamine → 4-(2-hydroxyphenyl)-N-methylbutyramide

HRID 1712416ノート

反応式

HRID 1712416 の反応式
[O:1]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[CH3:13][NH2:14]>C(O)(C)C>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][CH2:6][C:7]([NH:14][CH3:13])=[O:8]

参加物

4

反応物 2

HCID 6329MethylamineHCID 109757954,5-Dihydrobenzo[b]oxepin-2(3H)-one

生成物 1

HCID 685011294-(2-hydroxyphenyl)-N-methylbutyramide

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A solution of 1.0 g of 4,5-dihydro-3H-benzo[b]oxepin-2-one and 40 ml of 10% methylamine in isopropanol is heated in an autoclave at 100° C. over 16 hours. The reaction mixture is cooled to room temperature and concentrated by evaporation. The title compound is obtained as white crystals from the residue by means of flash chromatography (SiO2 60F). Rf=0.20 (4:1 EtOAc-heptane); Rt=2.66.

後処理

  1. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-6768a72d9dd04b2ca83714d19e1fb743
出典データセット
uspto-grants-2010_09
特許番号
US07790715B2

反応ノート

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