Hydrochloric Acid → 2-(6-methylpyridazin-3-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine hydrochloride
反応式
[CH3:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH:23]=[C:11]3[CH2:12][N:13](C(OC(C)(C)C)=O)[CH2:14][CH2:15][C:10]3=[N:9]2)=[CH:4][CH:3]=1.[ClH:24]>O1CCOCC1>[ClH:24].[CH3:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH:23]=[C:11]3[CH2:12][NH:13][CH2:14][CH2:15][C:10]3=[N:9]2)=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of tert-butyl 2-(6-methylpyridazin-3-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (2.38 g, 7.55 mmol) in dioxane (20 ml) is added 4N HCl in dioxane (20 mL, 80 mmol) and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 216.2.
後処理
- customThe solvent is removed
- washthe residue is washed with ether
出典と根拠
- ORDレコード
- ord-1a81c132f6a54bf5a36d1c6aca047ca3
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07795262B2
反応ノート
読み込み中…