Triethylamine → 8-(4-Bromobenzylamino)adenosine

HRID 1713259ノート

反応式

HRID 1713259 の反応式
Br[C:2]1[N:3]([C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH2:20])[C:18]=2[N:19]=1)[C@@H:4]1[O:12][C@H:9]([CH2:10][OH:11])[C@@H:7]([OH:8])[C@H:5]1[OH:6].Cl.[Br:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1.C(N(CC)CC)C>C(O)C>[Br:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH:28][C:2]2[N:3]([C:13]3[N:14]=[CH:15][N:16]=[C:17]([NH2:20])[C:18]=3[N:19]=2)[C@@H:4]2[O:12][C@H:9]([CH2:10][OH:11])[C@@H:7]([OH:8])[C@H:5]2[OH:6])=[CH:25][CH:24]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 965448-BromoadenosineHCID 27240964-Bromobenzylamine hydrochloride

生成物 1

HCID 674555318-(4-Bromobenzylamino)adenosine収率 90.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 8-bromoadenosine (0.100 g), 4-bromobenzylamine hydrochloride (0.193 g) and triethylamine (0.201 mL) in ethanol (2.9 mL) was stirred under reflux for 96 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography on aminopropylated silica gel (eluent: dichloromethane/methanol=10/1) to give the title compound (0.118 g).

後処理

  1. temperatureunder reflux for 96 hours
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by column chromatography on aminopropylated silica gel (eluent: dichloromethane/methanol=10/1)

出典と根拠

ORDレコード
ord-639b01dafef94996920f61aa46db08fb
出典データセット
uspto-grants-2010_09
特許番号
US07795236B2

反応ノート

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