3-Benzoyluracil → Benzoic acid 5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pentyl ester

反応式

[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16]([N:24]1[C:29](=[O:30])[CH:28]=[CH:27][NH:26][C:25]1=[O:31])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([N:24]1[C:29](=[O:30])[CH:28]=[CH:27][N:26]([CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][O:9][C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:25]1=[O:31])(=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

反応物 2

HCID 5695133-Benzoyluracil

HCID 5698735-Hydroxypentyl benzoate

生成物 1

HCID 11640071Benzoic acid 5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pentyl ester収率 50%

実験手順

The title compound (50%) was prepared as described in example 15 but using the alcohol 20 instead of 14 in the coupling reaction with N3-benzoyluracil.

出典と根拠

ORDレコード: ord-54b93a12a5544175ae0a9a3cf44e89cf
出典データセット: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07795270B2

反応ノート

読み込み中…