Sodium Bicarbonate → Ethyl 1,4-dibenzylpiperazine-2-carboxylate
反応式
Cl.Cl.[C:3]1([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:12][CH:11]2[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])O.[Na+]>>[C:3]1([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:12][CH:11]2[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
3
実験手順
Ethyl 1,4-bis(phenylmethyl)-2-piperazine carboxylate dihydrochloride (21 g, 52 mmol) was neutralized with an aqueous sodium hydrogen carbonate solution, and then extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and then concentrated under reduced pressure to obtain the title compound (18 g, quantitative). The obtained compound was used in the next process without further purification.
後処理
- extractionextracted with ethyl acetate
- washThe extract was washed with water
- dry with materialdried over magnesium sulfate