Boron tribromide → 4-(2-Phenylamino-thiazol-5-yl)-phenol

HRID 1713648ノート

反応式

HRID 1713648 の反応式
N1(CCO[C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]3[S:17][C:18]([C:21]4[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=4)=[CH:19][N:20]=3)=[CH:11][CH:10]=2)CCCC1.COC1C=CC(C2SC(NC3C=CC=CC=3)=NC=2)=CC=1.B(Br)(Br)Br>C(Cl)Cl.CO>[C:12]1([NH:15][C:16]2[S:17][C:18]([C:21]3[CH:22]=[CH:23][C:24]([OH:27])=[CH:25][CH:26]=3)=[CH:19][N:20]=2)[CH:11]=[CH:10][CH:9]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 25134Boron tribromideHCID 111882064-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenolHCID 58923516[5-(4-Methoxy-phenyl)-thiazol-2-yl]-phenyl-amine

生成物 1

HCID 589235364-(2-Phenylamino-thiazol-5-yl)-phenol

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The title compound is prepared as described in Example 7 for 4-{2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol but starting from [5-(4-methoxy-phenyl)-thiazol-2-yl]-phenyl-amine and using 2 equivalents of BBr3. Title compound: ES-MS: 269.0 [M+H]+; single peak at tR=6.65 min (System 1); Rf=0.05 (CH2Cl2/MeOH, 98/2).

後処理

  1. customThe title compound is prepared

出典と根拠

ORDレコード
ord-5129ac82db3047d6aebf25bee26a5146
出典データセット
uspto-grants-2010_09
特許番号
US07795288B2

反応ノート

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