{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine → [4-(2-Dimethylamino-ethoxy)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine

HRID 1713654

反応式

HRID 1713654 の反応式
[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4]COC1C=CC(C2SC(NC3C=CC=CC=3)=NC=2)=CC=1.[S:26]1[CH:30]=[CH:29][C:28]([C:31]2[S:35][C:34]([NH:36][C:37]3[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=3)=[N:33][CH:32]=2)=[CH:27]1.Cl.ClCCN(C)C>C(Cl)Cl.CO>[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][O:43][C:40]1[CH:41]=[CH:42][C:37]([NH:36][C:34]2[S:35][C:31]([C:28]3[CH:29]=[CH:30][S:26][CH:27]=3)=[CH:32][N:33]=2)=[CH:38][CH:39]=1

参加物

5

反応物 3

HCID 11245147{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amineHCID 112888354-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenolHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

生成物 1

HCID 11279419[4-(2-Dimethylamino-ethoxy)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol (Example 12) and using 1-chloro-2-dimethylaminoethane hydrochloride. Title compound: ES-MS: 346.0 [M+H]+; single peak at tR=5.89 min (System 1); Rf=0.34 (CH2Cl2/MeOH, 90/10).

後処理

  1. customThe title compound is prepared

出典と根拠

ORDレコード
ord-1d650799f4174755a70f079724df594d
出典データセット
uspto-grants-2010_09
特許番号
US07795288B2

関連ノート

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