Cesium carbonate → 4-(4-Nitro-imidazol-1-yl)-benzoic acid methyl ester

HRID 1714281ノート

反応式

HRID 1714281 の反応式
[N+:1]([C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)([O-:3])=[O:2].I[C:10]1[CH:18]=[CH:17][C:13]([C:14]([O-:16])=[O:15])=[C:12](C)[CH:11]=1.[C:20](=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.[O-]S(C(F)(F)F)(=O)=O.[Cu+]>[CH3:20][O:16][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][C:10]([N:7]2[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]2)=[CH:11][CH:12]=1

参加物

6

反応物 3

HCID 10796Cesium carbonateHCID 226178964-Iodo-methylbenzoateHCID 178526856HCID 178526856、化合物

生成物 1

HCID 671649044-(4-Nitro-imidazol-1-yl)-benzoic acid methyl ester

試薬・触媒・溶媒 2

HCID 9813164Copper(I) trifluoromethanesulfonate触媒HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

4-nitroimidazole (1 equiv) was combined with 4-iodo-methylbenzoate (1.2 equiv), cesium carbonate (1.0 equiv), copper (I) triflate (0.05 equiv), in DMF and heated overnight at 100° C. The solid was filtered and washed with methylene chloride, the resultant solvent was concentrated, and residue purified by silica gel chromatography to provide the title compound: MS m/z 248.2 (M+1).

後処理

  1. filtrationThe solid was filtered
  2. washwashed with methylene chloride
  3. concentrationthe resultant solvent was concentrated
  4. customresidue purified by silica gel chromatography

出典と根拠

ORDレコード
ord-75e299f5a89143aa81ec61b75c368edb
出典データセット
uspto-grants-2010_09
特許番号
US07795447B2

反応ノート

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