Acetone → 1-(2-Amino-7H-purin-6-yl)-1-methylpyrrolidinium Chloride
反応式
[CH:1]1[NH:2][C:3]2[N:9]=[C:8]([NH2:10])[N:7]=[C:6]([Cl:11])[C:4]=2[N:5]=1.[CH3:12][N:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1.CC(C)=O>CN(C=O)C>[Cl-:11].[NH2:10][C:8]1[N:9]=[C:3]2[C:4]([NH:5][CH:1]=[N:2]2)=[C:6]([N+:13]2([CH3:12])[CH2:17][CH2:16][CH2:15][CH2:14]2)[N:7]=1参加物
5
実験手順
1.0 g (5.9 mmol) 6-Chloroguanine is dissolved in 40 mL DMF at 40° C. After cooling to room temperature, 1.4 mL 1-methylpyrrolidine (13.2 mmol) is added, and the reaction mixture is stirred for 18 h. 2 mL of acetone are added to complete precipitation. The solid is filtered, washed with ether and dried in vacuo, yielding 1.03 g 27 (3.9 mmol, 66%).
後処理
- filtrationThe solid is filtered
- washwashed with ether
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-b583a143732c44949f8a3f6528b3a40e
- 出典データセット
- uspto-grants-2010_09
- 特許番号
- US07799524B2
反応ノート
読み込み中…