関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 8-Iodo-3-(phenylsulfonyl)quinoline | HCID 11406774 | — |
| 反応物 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | Bis(cyclopenta-2,4-dien-1-yl(phenyl)phosphane);iron(2+) | HCID 133083342 | — |
| 生成物 | 8-(4-Methyl-piperazin-1-yl)-3phenylsulfonylquinoline | HCID 9929162 | — |
反応手順
8-Iodo-3-phenylsulfonyl-quinoline (D6) (190 mg, 0.48 mmol), N-methyl-piperazine (48 mg, 0.48 mmol), sodium tertbutoxide (65 mg, 0.68 mmol), di-palladium tetrakis-(dibenzylidine acetone) [Pd2(dba)3] (88 mg, 0.1 mmol) and 1,1′-diphenylphosphino ferrocene (161 mg, 0.3 mmol) were suspended in degassed dry dioxan (2 ml). The mixture was stirred under argon at 40° C. for 16 hours. The solvent was removed and the residue subjected to flash chromatography on silica gel (eluting with dichloromethane-methanol aq. ammonia) to give the title compound (E1), identical spectroscopically to that prepared by the earlier methods.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07799774B2 |
|---|
| 出典データセット | uspto-grants-2010_09 |
|---|
| ORD ID | ord-a30beed5802649d7baec50e4aea8984b |
|---|
| 出典メモ | uspto-grants-2010_09 |
|---|
