Hydroxylamine → HCID 54592521、化合物

HRID 1715260ノート

反応式

HRID 1715260 の反応式
[C:1]([CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])#[N:2].[NH2:13][OH:14]>CCO>[NH2:2]/[C:1](=[N:13]/[OH:14])/[CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10]

参加物

4

反応物 2

HCID 787HydroxylamineHCID 2735664tert-butyl N-(2-cyanoethyl)carbamate

生成物 1

HCID 54592521HCID 54592521、化合物収率 99.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Tert-butyl N-(2-cyanoethyl)carbamate (40 g; 235 mmol; 1 eq.) and hydroxylamine (41.6 ml; 705 mmol; 3 eq.) are dissolved in EtOH (800 ml). The resulting solution is heated under reflux for 2 hours. The reaction progression is followed by 1H NMR. After 2 hours, the reaction mixture is cooled down to RT, concentrated under high vacuum to afford the title compound as a white solid (47.5 g, 99%).

後処理

  1. temperatureThe resulting solution is heated
  2. temperatureunder reflux for 2 hours
  3. concentrationconcentrated under high vacuum

出典と根拠

ORDレコード
ord-5de7d2eb2a6f410a983d759a63b62271
出典データセット
uspto-grants-2010_09
特許番号
US07799814B2

反応ノート

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