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Triethylamine → N-[2-(cyanomethyl)-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl]-N'-[2-(5-isopropyl-1,2,4-oxadiazol-3-yl)ethyl]urea

HRID 1715302
ノート
印刷プレビュー

反応式

HRID 1715302 の反応式
[CH:1]([C:4]1[O:8][N:7]=[C:6]([CH2:9][CH2:10][NH2:11])[N:5]=1)([CH3:3])[CH3:2].[CH2:12]([N:14](CC)CC)C.[C:19]([NH:22][C:23]1[S:24][C:25]([C:29]2[N:30]=[C:31]([C:34](NCC3CCCO3)=O)[S:32][CH:33]=2)=[C:26]([CH3:28])[N:27]=1)(=[O:21])C>CN(C=O)C>[C:12]([CH2:34][C:31]1[S:32][CH:33]=[C:29]([C:25]2[S:24][C:23]([NH:22][C:19]([NH:11][CH2:10][CH2:9][C:6]3[N:5]=[C:4]([CH:1]([CH3:3])[CH3:2])[O:8][N:7]=3)=[O:21])=[N:27][C:26]=2[CH3:28])[N:30]=1)#[N:14]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 8471TriethylamineHCID 119895252'-(Acetylamino)-4'-methyl-N-(tetrahydrofuran-2-ylmethyl)-4,5'-bi-1,3-thiazole-2-carboxamide2 回HCID 176049972-(5-(Propan-2-yl)-1,2,4-oxadiazol-3-yl)ethan-1-amine

生成物 1

HCID 11988783N-[2-(cyanomethyl)-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl]-N'-[2-(5-isopropyl-1,2,4-oxadiazol-3-yl)ethyl]urea

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

実験手順

2-(5-Isopropyl-1,2,4-oxadiazol-3-yl)ethanamine (Amine 16) (129.2 mg; 0.48 mmol; 2 eq) is dissolved in DMF (4 ml). Triethylamine (133 μl; 0.96 mmol; 4 eq) and N-[2-(cyanomethyl)-4′-methyl-4,5′-bi-1,3-thiazol-2′-yl]-1H-imidazole-1-carboxamide (Intermediate 6) (79.3 mg; 0.24 mmol; 1 eq) are added. After less than 1 min the mixture becomes homogeneous, and after 30 min the reaction is complete. Solvents are evaporated and the resulting crude product is purified by preparative HPLC. The purified fractions are neutralized with NaHCO3 sat. solution and the desired product is extracted with DCM. The combined organic layers are dried over MgSO4, filtered and concentrated to Compound (82) as a white powder (29.6 mg; 30%).

後処理

  1. waitAfter less than 1 min the mixture becomes homogeneous
  2. customSolvents are evaporated
  3. customthe resulting crude product is purified by preparative HPLC
  4. extractionthe desired product is extracted with DCM
  5. dry with materialThe combined organic layers are dried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated to Compound (82) as a white powder (29.6 mg; 30%)

出典と根拠

ORDレコード
ord-97a1fd9d9eed4e2b9cd1e0c608ad8d60
出典データセット
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07799814B2

反応ノート

読み込み中…

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