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Triethylamine → N-(2-Oxo-2-phenylethyl)-5-(fluoroacetyl)thiophene-2-carboxamide

HRID 1715354
ノート
印刷プレビュー

反応式

HRID 1715354 の反応式
F[C:2]([F:14])(F)[C:3]([C:5]1[S:9][C:8]([C:10]([OH:12])=O)=[CH:7][CH:6]=1)=[O:4].N=C=N.Cl.[NH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22].CCN(CC)CC>C(Cl)Cl>[O:22]=[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:20][NH:19][C:10]([C:8]1[S:9][C:5]([C:3](=[O:4])[CH2:2][F:14])=[CH:6][CH:7]=1)=[O:12]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 8471TriethylamineHCID 160435CarbodiimideHCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)HCID 242747015-(2,2,2-Trifluoroacetyl)thiophene-2-carboxylic acid

生成物 1

HCID 86628838N-(2-Oxo-2-phenylethyl)-5-(fluoroacetyl)thiophene-2-carboxamide

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒
2 回

実験手順

To a solution of Example 1, A1 in DCM was added Pol-supported carbodiimide (2 eq) and the suspension was stirred at RT for 30 min. A solution of 2-aminoacetophenone HCl (1.1 eq) and Et3N (1.1 eq) in DCM was added and the resulting suspension was stirred at RT overnight. The resin was filtered, washed with DCM, and the filtrate was evaporated at reduced pressure. Purification by flash chromatography on silica gel eluting with DCM gave the title compound as a solid.

後処理

  1. stirringthe resulting suspension was stirred at RT overnight
  2. filtrationThe resin was filtered
  3. washwashed with DCM
  4. customthe filtrate was evaporated at reduced pressure
  5. customPurification by flash chromatography on silica gel eluting with DCM

出典と根拠

ORDレコード
ord-8ee931b835914bd4a9f23d64613a623f
出典データセット
uspto-grants-2010_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07799825B2

反応ノート

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