化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → Irbesartan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Irbesartan hydrochloride | HCID 11568906 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Irbesartan | HCID 3749 | — |
反応手順
100 g of anhydrous irbesartan hydrochloride was taken in a mixture of 250 ml toluene and 250 ml water. The pH of the reaction mass was adjusted to 6.5 to 7.0 with aqueous ammonia at 25-30° C. and stirred for about 30 minutes and filtered. The product was dried at 60° C. under vacuum to yield Form A of irbesartan free base.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07799928B2 |
| 出典データセット | uspto-grants-2010_09 |
| ORD ID | ord-63630d540c32495c932d321ae0909986 |
| 出典メモ | uspto-grants-2010_09 |