3-Benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one → 3-Hydroxy-1-(toluene-4-sulfonylmethyl)-1h-pyridin-2-one

HRID 1716306ノート

反応式

HRID 1716306 の反応式
C([O:8][C:9]1[C:10](=[O:26])[N:11]([CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CS(O)(=O)=O>[OH:8][C:9]1[C:10](=[O:26])[N:11]([CH2:15][S:16]([C:19]2[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=2)(=[O:18])=[O:17])[CH:12]=[CH:13][CH:14]=1

参加物

3

反応物 1

HCID 685103983-Benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one

生成物 1

HCID 444558373-Hydroxy-1-(toluene-4-sulfonylmethyl)-1h-pyridin-2-one

試薬・触媒・溶媒 1

HCID 6395Methanesulfonic Acid溶媒

実験手順

A solution of 3-benzyloxy-1-(toluene-4-sulfonylmethyl)-1H-pyridin-2-one (50 mg) from Step B in MeSO3H (1.5 mL) was stirred at room temperature for 20 min and then quenched with ice water. The solid was filtered off and washed with water. The crude product was re-dissolved in hot MeOH (1 mL) and removed un-dissolved brownish solid. The filtrate was concentrated in vacuo to give the titled compound. MS (EI) 280 (M+H)+.

後処理

  1. customquenched with ice water
  2. filtrationThe solid was filtered off
  3. washwashed with water
  4. dissolutionThe crude product was re-dissolved in hot MeOH (1 mL)
  5. customremoved
  6. dissolutionun-dissolved brownish solid
  7. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-769f85478d454fe49c95ee592e78da34
出典データセット
uspto-grants-2010_09
特許番号
US07803793B2

反応ノート

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