Hydrochloric Acid → HCID 68513196、化合物

HRID 1716596ノート

反応式

HRID 1716596 の反応式
C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[CH2:13][CH:12]([C:17]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]3[C:29]4[CH:30]=[CH:31][C:32]([CH3:34])=[CH:33][C:28]=4[N:27]=[C:26]3[C:35]([OH:38])([CH3:37])[CH3:36])[CH2:21][CH2:20]1)=[O:18])[CH2:11]2)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[CH2:13][CH:12]([C:17]([N:19]1[CH2:20][CH2:21][CH:22]([N:25]3[C:29]4[CH:30]=[CH:31][C:32]([CH3:34])=[CH:33][C:28]=4[N:27]=[C:26]3[C:35]([OH:38])([CH3:36])[CH3:37])[CH2:23][CH2:24]1)=[O:18])[CH2:11]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68513435HCID 68513435、化合物

生成物 1

HCID 68513196HCID 68513196、化合物収率 95%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of (2-{4-[2-(1-hydroxy-1-methyl-ethyl)-5-methyl-benzoimidazol-1-yl]-piperidine-1-carbonyl}-indan-5-yl)-carbamic acid tert-butyl ester (266 mg, 0.49 mmol) in dioxane (2 mL) was added 4 M HCl (2 ml). After the addition was complete, the reaction mixture was stirred for 1 hour. The solvent mixture was quenched with saturated NaHCO3 and extracted with ethyl acetate, the extracts was dried over Na2SO4 and concentrated to afford (5-amino-indan-2-yl)-{4-[2-(1-hydroxy-1-methyl-ethyl)-5-methyl-benzoimidazol-1-yl]-piperidin-1-yl}-methanone (200 mg 95%) as a white solid.

後処理

  1. additionAfter the addition
  2. customThe solvent mixture was quenched with saturated NaHCO3
  3. extractionextracted with ethyl acetate
  4. dry with materialthe extracts was dried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-26dd5e4fa5284e19aff5ac4109290e92
出典データセット
uspto-grants-2010_09
特許番号
US07803816B2

反応ノート

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